Editor s note: as of 4:45 pm ET, the Lions vs 49ers game total has increased a full point to 52.5 (-110 both ways). The spread and total remain the same.
As a touchdown favorite and -358 on the moneyline, San Francisco are heavy favorites in the Lions vs 49ers odds and have an implied probability of 78.17. Oddsmakers are expecting points to be scored with a total set at 51.5 points in the Over/Under.
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